Founded in 1962 by the Brothers of the Christian School, De Salle Lipa was built on a 5.9 hectare lot along the national highway. Financed by interest-free loans from Caltex and Shell Corporations, construction of the three one-storey wings of classrooms, a gymnasium-auditorium and the Brothers' House began on January 1962. During its first year, DLSL operated as the Boy's Department of the Maryknoll Sisters' Our Lady of the Rosary Academy (OLRA). As the Maryknoll Sisters were phasing out OLRA's Boys' Department, 221 students were admitted from first to fourth year.


Three Brothers and seven lay teachers composed the first staff of the school. Br. Henry Virgil FSC was the first Director and Principal.


On its second year of operations, the school obtained a temporary permit to operate as La Salle High School. After one year and seven months of guiding the fledgling institution, Br. Virgil died of a heart attack on the 22nd of September 1963. Br. Hugh Damian took his place and held the helm for the next two years.


The school population more than doubled during its fourth year operations. This necessitated the construction of the two-storey St. Joseph Hall during the administration of Br. Frederick Martin FSC in 1967.


Towards the end of the decade as OLRA continued to send its boys to La Salle High School, a large percentage of students began to come from the various elementary schools around the city. Thus, to better prepare the students for the high school, the elementary grades were opened in 1967, with Br. Vernon Mabile FSC as Principal.


In 1969, Br. Rafael Donato FSC arrived to become Director and Principal. It was during his term that the new school seal was designed. The tradition of staging an annual school fair was also begun.


After Br. Rafael's departure for La Salle Greenhills in 1970, Br. Crisanto Moreno FSC became the Principal. Br. Gregory Refuerzo FSC was then the Director. During the term of the two in office, a new library and a sports complex were constructed. The faéade was improved and wooden bleachers inside the gymnasium were constructed. The school became known as De La Salle of Lipa.


Girls were first accepted in school year 1974-75 when Br. Emiliano Hudtohan FSC was the principal. The girls, however, were limited to the first and second year levels.


It was during the term of Br. Antonio Narciso FSC that the school's incorporation papers and by-laws were amended. The school was officially registered with the Securities and Exchange Commission as De La Salle Lipa, Inc.


An attempt at securing PAASCU accreditation was made during the term of Br. Jaime de Guzman FSC. His term of office was remembered for the construction of the four grade school classrooms, which would eventually be known as the Immaculate Conception Hall.


During the term of Br. Samuel Bueser FSC late in the seventies, a modified split-schedule for freshmen and sophomores was implemented to accommodate the growing student population. Enrolment has soared to 1,200. Another effort was made to gain PAASCU accreditation, and this, along with moves to open a College Department, came to fruition after Br. Samuel's term was completed.


In school year 1982-1983, DLSL received its first High School PAASCU accreditation. Br. Eugenio Tianco FSC was the Principal, while Br. Gregory returned to occupy the Director's position. During the school year, an extension to the library was constructed along with an office for guidance counseling. Also, Immaculate Conception Hall was completed during the summer.


Br. Jaime Dalumpines FSC was appointed Principal in 1983. Because of recommendations contained in the PAASCU report, reforms were instituted. The two-year old split schedule for freshmen and sophomores was scrapped. Administration was decentralized and Year Level Moderators were introduced for improved student supervision.


In 1985, the College Department came into existence with an enrollment of 130 students. The College offered Bachelor of Science in Commerce Major in Business Management and Agribusiness Management.


Br. Jaime went on to complete a 5-year term, the last of which was school year 1987-88. He left soon afterwards for Canada for further studies, and was replaced by Br. Edgardo Jayme FSC. The latter stayed for only a few months and left the school in midterm. Ms. Norma Blanco was appointed Acting Principal, assisted by a council composed of the Year Level Moderators and Department Heads.


Ms. Blanco was formally appointed as the first lay principal of the high school the following May. During Ms. Blanco's term, the 1100 wing was constructed to house the freshmen classes. Also, the Elementary Department was reopened.


Because of the rapid growth of the institution in the nineties, it became necessary in 1994 to have a resident president. The position was given to alumnus Br. Narciso Erguiza FSC, who, in 1974, was briefly assigned to the school but had spent most of his years as a De La Salle Brother elsewhere.


Br. Erguiza stayed for two school years and reorganized the administrative structure. The major academic and service departments became known as "units" and their respective heads sat in the President's Council, which met weekly. Strategic directions were drafted and implemented, which emphasized the growing role of the college in the community.


Also, in the nineties, the College Department added more courses such as Secretarial Administration; Agribusiness Management with majors in Horticulture and Animal Husbandry; Bachelor of Elementary Education; Bachelor of Secondary Education with majors in English, Math, Religious Education and Environmental Science; and Bachelor of Science in Computer Science, Accountancy and Hotel and Restaurant Management.


With Br. Erguiza requesting to pursue fulltime graduate studies at the end of his school year in office, Br. Donato was requested by Bro. Benildo Feliciano FSC, the Brother Provincial, to become President of the school. The latter accepted and was officially installed in ceremonies held on 15th May 1995.


Under Br. Donato's term, De La Salle Lipa embarked on a massive physical plant development program which completely transformed the Institution. Various innovations were also introduced. The elementary and secondary units were integrated into what is known as the Unified School, with homerooms named after parishes, Philippine cities and cities around Southeast Asia and Oceana region where De La Salle schools are located.


A graduate program was offered for the first time in the school's history. The school's Master in Management Technology program, the first of its kind in the Philippines, combines Business Management with Information Technology.


More courses offerings were made available in the Tertiary School at the turn of the century as programs in Secretarial Administration and Agribusiness Management were phased out. Courses in Financial Management, Bachelor of Science in Engineering, Economics, Management Technology, Legal Management, and Certificate Courses in Entrepreneurship, Hotel and Restaurant Management and Information Technology were opened. In the later years, Bachelors of Science in Psychology, Electronics and Communication, Bachelor of Science in Psychology, Electronics and Communications Engineering, Industrial Engineering, Bachelor of Arts in Communication, Bachelor of Science in Mathematics, Nursing, Tourism, Bachelor of Science in Entrepreneurship, Biology and Electrical Engineering were also offered.


Br. Donato retired in 2003 after having presided over the most intensive period of growth and development that the school had ever known. Br. Manuel Pajarillo FSC was installed as 3rd president of DLSL on 15 May 2003.


Under Br. Manuel Pajarillo's term, the grade school and the high school levels of the Unified School (re-named later as the Integrated School under the supervision of its Principal, Ms. Violeta Ramirez) received their Level 2 "clean" re-accreditation status for five years from PAASCU. This was the highest rating received by the high school level since 1983 and the initial 5-years accreditation status for the grade school level.


The College, with its goal of improving its academics program submitted applications for the PAASCU accreditation of the following programs: Business Management, Education, Accountancy, Hotel and Restaurant Management, Marketing Management, Economics, Computer Science, and Financial Management. Business Management and Education were granted Level 1 accreditation status in 2005 while the rest had their preliminary visit the year after.


New facilities were built and information technology was improved. The Apolinario Mabini and the St. Br. Benilde buildings were constructed to provide facilities for the Sciences Courses in College and new classrooms for the Primary Learning Community of the Integrated School respectively. Wireless Internet Connectivity was introduced to keen abreast with new trends in Information and Technology.


In school year 2005-2006, changes in the school's seal, vision-mission statement, organizational structure and nomenclature were implemented in response to new changes in Lasallian education. Buildings in Integrated School were named after saints and a Lasallian Brother (Br. Gregory Refuerzo FSC) while college buildings were named after Philippine heroes and prominent Batangueños.

In the same school year, Br. Manuel Pajarillo FSC launched the Book Mobile Reading Program (BMRP), a bus converted into a moving library to cater to the reading and literacy needs of the public schools that surround DLSL. The program hopes, among others, to provide the students of beneficiary schools with reading materials suited to their level and interest; enough information on library procedures; information and exercises to develop students' reading skills; and, creative activities to develop students' interest in reading.

In 2006, Br. Manuel Pajarillo FSC was assigned as Interim President of the De La Salle University Dasmariñas and the De La Salle Health and Science Campus while serving as President of DLSL.


Until the end of his term in SY 2009-2010, Br. Manuel Pajarillo FSC stood by the 10-point agenda, forming the DLSL's strategic direction during his term. These revolved around Educational Excellence, Academic Competence, Scholarship and Innovation, Synergy, Accountability, Internationalization, Lasallian Association, Education of and for the Poor, Justice and Pro-Environment Practices and
Social Transformation.


In SY 2010-2011, Br. Joaquin S. Martinez FSC became the 4th resident Brother President of De La Salle Lipa. The previous administrations' 10-point agenda was now condensed into Five Pillars of Direction: DLSL as a Learning Organization, Diversified Funding Base, Accessibility, Care and Nurturance of the Environment and Community Development and Transformation.


Early in his administration, physical improvement and maintenance of existing structures and landscaping were noticeable. The continuation of the Brother Benilde Building also took place as well as the renovation of the canteen area into the Animo Diner and the Green Spoon Café. His administration is also credited for acquiring almost 4 hectares of land beside De La Salle Lipa which is planned to house future expansion of the College and Institutional structures of the institution.