DLSL belongs to the third generation of schools founded by the De La Salle Brothers in the Philippines. The mother school, De La Salle University, Manila, was opened in 1911. The second foundation did not come into being until 1952 when La Salle College was established in Bacolod City, Negros Occidental. The third group of foundations is composed of La Salle Academy (Iligan City, Lanao del Norte) in 1958, La Salle Greenhills (Mandaluyong) in 1959, St. Joseph’s High School (Villamonte, Bacolod City) in 1960 and lastly, De La Salle Lipa in 1962.
   The school was built on a 5.9 hectare lot along the National Highway. Construction of three one-storey wings of classrooms, a gymnasium-auditorium and the Brothers’ House began on 29 January 1962.
   During its first year, DLSL had to operate as the Boys’ Department of the Maryknoll Sisters’ Our Lady of the Rosary Academy (OLRA). As the Maryknoll Sisters were phasing out OLRA’s Boy’s Department, 221 students were admitted from first to fourth year.
   On its second year of operations, the school obtained a temporary permit to operate as La Salle High School.
   After one year and seven months of guiding the fledgling institution, Br. Virgil died of a heart attack on 22 September 1963. Br. Hugh Damian took his place and held the helm for the next two years. The school population more than doubled during its fourth year of operations. This necessitated the construction of the two-storey St. Joseph’s Hall during the administration of Br. Frederick Martin (later known as Br. Raymond Bronowicz) in 1967.
   While OLRA continued to send its boys into La Salle, a large percentage of students towards the end of the decade began to come from the various public elementary schools around the city. Thus, to better prepare students for the high school, the elementary grades were opened in 1967, with Br. Vernon Mabile as Principal.
   Girls were first accepted in schoolyear 1974-75, when Br. Emiliano Hudtohan was Principal. The girls, however, were limited to the first and second year levels.